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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
IL10 - Interleukin 10
Alias:
CSIF
TGIF
GVHDS
IL-10
IL10A
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种主要由单核细胞产生的细胞因子,其次由淋巴细胞产生。这种细胞因子在免疫调节和炎症中具有多效性作用。它下调巨噬细胞上Th1细胞因子、MHC II抗原和共刺激分子的表达。它还增强B细胞的存活、增殖和抗体产生。这种细胞因子可以阻断NF-kappa B活性,并参与JAK-STAT信号通路的调节。在小鼠中进行的敲除研究表明,这种细胞因子在肠道中具有重要的免疫调节功能。这种基因的突变与对HIV-1感染和类风湿关节炎的易感性增加有关。[由RefSeq提供,2020年5月]
Related ID:
NCBI:3586
ENSEMBL:ENSG00000136634
HGNC:5962
UNIPROT:P22301
OMIM:124092
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
3586
2
5
4893 bp
20.52
102
6
18
21
IL10 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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No data available
Transcripts & Proteins
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Transcript
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Name
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CAS Number
Status
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Link
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References Literature
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IF
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