人类

IL10 - Interleukin 10

Alias:
CSIF
TGIF
GVHDS
IL-10
IL10A
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种主要由单核细胞产生的细胞因子,其次由淋巴细胞产生。这种细胞因子在免疫调节和炎症中具有多效性作用。它下调巨噬细胞上Th1细胞因子、MHC II抗原和共刺激分子的表达。它还增强B细胞的存活、增殖和抗体产生。这种细胞因子可以阻断NF-kappa B活性,并参与JAK-STAT信号通路的调节。在小鼠中进行的敲除研究表明,这种细胞因子在肠道中具有重要的免疫调节功能。这种基因的突变与对HIV-1感染和类风湿关节炎的易感性增加有关。[由RefSeq提供,2020年5月]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
2
5
4893 bp
20.52
102
6
18
21

IL10 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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