人类

CXCR2 - C-X-C Motif Chemokine Receptor 2

Alias:
CD182
IL8R2
IL8RA
IL8RB
CMKAR2
WHIMS2
CDw128b
Favorite
Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是G蛋白偶联受体家族的成员。这个蛋白质是白细胞介素8(IL8)的受体。它以高亲和力与IL8结合,并通过G蛋白激活的第二信使系统传递信号。这个受体还可以与趋化素(C-X-C基序)配体1(CXCL1/MGSA)结合,这是一种具有黑色素瘤生长刺激活性的蛋白质,已经证明是血清依赖性黑色素瘤细胞生长所需的主要成分。这个受体介导中性粒细胞向炎症部位的迁移。在肠道微血管内皮细胞中,IL8的血管生成作用发现是由这个受体介导的。在小鼠中的敲除研究提示,这个受体通过阻止其迁移来控制少突胶质细胞前体在发育中的脊髓中的定位。这个基因,IL8RA,一个编码另一个高亲和力IL8受体的基因,以及IL8RBP,IL8RB的假基因,在定位到染色体2q33-q36的区域中形成一个基因簇。已经发现了编码相同蛋白质的替代剪接变体。[RefSeq,2009年11月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
9
3
11958 bp
40.76
151
2
8
12

CXCR2 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
Wechat
Mutation Direct
Sequence
Comparison
Al agent
Tutorials
Back to top