人类

IL7 - Interleukin 7

Alias:
IL-7
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种对B和T细胞发育重要的细胞因子。这种细胞因子与肝细胞生长因子(HGF)形成异源二聚体,作为前B细胞生长刺激因子发挥作用。IL7在早期T细胞发育过程中被发现在T细胞受体β(TCRB)的V(D)J重排过程中是一个辅因子。这种细胞因子可以在局部由肠道上皮细胞和杯状上皮细胞产生,并可能作为肠道黏膜淋巴细胞的调节因子。IL7在淋巴样细胞存活和维持原始和记忆T细胞方面发挥重要作用。替代剪接产生多个编码不同异质体的转录本变异体。已经描述了其他的剪接变异体,但它们在正常组织中的存在尚未得到证实。严重急性呼吸综合症冠状病毒2感染(SARS-CoV-2)可以强烈诱导抗炎细胞因子和趋化因子,这可能对抗感染,也可能介导破坏性的肺损伤。已发现升高的血清IL7水平与其他几个循环细胞因子和趋化因子一起与冠状病毒疾病19(COVID-19)的严重程度相关。[由RefSeq,2020年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
10
6
130420 bp
20.19
23
2
15
14

IL7 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
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