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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
IL5RA - Interleukin 5 Receptor Subunit Alpha
Alias:
IL5R
CD125
CDw125
HSIL5R3
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种异源二聚细胞因子受体的白细胞介素5特异性亚单位。该受体由配体特异性的α亚单位和信号传导β亚单位组成,这些亚单位由白细胞介素3(IL3)、集落刺激因子2(CSF2/GM-CSF)和白细胞介素5(IL5)的受体共享。这个蛋白质与IL5的结合依赖于β亚单位。β亚单位被配体激活,并是IL5生物活性的必需成分。已发现这个蛋白质与合成素(syntenin)相互作用,合成素是IL5介导的转录因子SOX4激活所必需的。已经报道了几种可变剪接的转录变异体,编码四种不同的异构体。[由RefSeq,2011年7月提供]
Related ID:
NCBI:3568
ENSEMBL:ENSG00000091181
HGNC:6017
UNIPROT:Q01344
OMIM:147851
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
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Reference
3568
9
12
44051 bp
47.69
22
--
4
11
IL5RA Genetics information (-)
GRCh38
Sequence Homology
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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