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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
IL2 - Interleukin 2
Alias:
IL-2
TCGF
lymphokine
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Description
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因是白细胞介素2(IL2)细胞因子亚家族的成员,包括IL4、IL7、IL9、IL15、IL21、红细胞生成素和血小板生成素。这个基因编码的蛋白质是一种由激活的CD4+和CD8+T淋巴细胞产生的分泌型细胞因子,对T和B淋巴细胞的增殖非常重要。这个细胞因子的受体(IL2R)是一种异源三聚体蛋白质复合物,其γ链也由IL4和IL7共享。这个基因在成熟胸腺细胞中的表达是单等位基因的,这代表了一种罕见的调控模式,用于精确控制单个基因的表达。在小鼠中类似基因的靶向破坏导致溃疡性结肠炎样疾病,这表明这个基因在抗原刺激免疫反应中具有基本作用。[RefSeq,2020年9月提供]
Related ID:
NCBI:3558
ENSEMBL:ENSG00000109471
HGNC:6001
UNIPROT:P60568
OMIM:147680
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
3558
1
4
5256 bp
17.63
2
--
12
25
IL2 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
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No data available
Transcripts & Proteins
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Transcript
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* This data comes from NCBI.
Gene Expression
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Name
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References Literature
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