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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
IL1RN - Interleukin 1 Receptor Antagonist
Alias:
DIRA
IRAP
IL1F3
IL1RA
MVCD4
IL-1RN
IL-1ra
IL-1ra3
ICIL-1RA
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是白细胞介素1细胞因子家族的一员。这个蛋白质抑制白细胞介素1α(IL1A)和白细泡介素1β(IL1B)的活性,并调节各种与白细胞介素1相关的免疫和炎症反应,特别是在感染和炎症的急性阶段。这个基因和另外五个密切相关的细胞因子基因在染色体2上形成一个大约跨越400kb的基因簇。这个基因的一个多态性与骨质疏松性骨折和胃癌的风险增加有关。已经报道了几种编码不同异型体的可变剪接转录本变异体。[由RefSeq,2020年8月提供]
Related ID:
NCBI:3557
ENSEMBL:ENSG00000136689
HGNC:6000
UNIPROT:P18510
OMIM:147679
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
3557
10
4
34655 bp
20.05
198
3
8
26
IL1RN Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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