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中文人类
GEN1 - GEN1 Holliday Junction 5' Flap Endonuclease
Alias:
Gen
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这个基因编码Rad2/Xeroderma pigmentosum group G核酸酶家族的一员，其成员的特征是N-末端和内部的Xeroderma pigmentosum group G核酸酶结构域，后面跟着螺旋-发卡-螺旋结构域和无序的C-末端结构域。这个基因编码的蛋白质参与霍利迪连接点的解决，这是同源重组和双链断裂修复过程中DNA共价连接的中间四元结构。该蛋白质通过在连接处创建双切口来解决问题，从而产生可以连接的切口双链产物。此外，该蛋白质定位到中心体，在那里它与中心体完整性的调节有关。可变剪接导致多个转录变异体。[由RefSeq，2016年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
GEN1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
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Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
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Score
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Name
MGI
Strain of Origin
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References Literature
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