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中文人类
APOE - Apolipoprotein E
Alias:
AD2
LPG
APO-E
ApoE4
LDLCQ5
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这个基因编码的蛋白质是乳糜微粒的主要载脂蛋白。它结合特定的肝脏和外周细胞受体，对富含甘油三酯的脂蛋白成分的正常分解代谢是必需的。这个基因在染色体19上与相关的载脂蛋白C1和C2基因聚类。这个基因的突变导致家族性低β脂蛋白血症，或称为III型高脂蛋白血症（HLP III），其中增加的血浆胆固醇和甘油三酯是由于乳糜微粒和VLDL残余物的清除受损所致。[由RefSeq，2016年6月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
APOE Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
