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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
IFNA2 - Interferon Alpha 2
Alias:
IFNA
IFNA2B
leIF A
IFN-alphaA
IFN-alpha-2
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因是染色体9上α干扰素基因簇的成员。编码的细胞因子是I型干扰素家族的一员,在病毒感染后产生,作为先天免疫反应的关键部分,具有强大的抗病毒、抗增殖和免疫调节特性。这种细胞因子与其他I型干扰素一样,结合由IFNAR1和IFNAR2组成的普遍表达的血浆膜受体,因此能够作用于几乎所有身体细胞。编码的蛋白质能有效减轻普通感冒的症状和持续时间,并治疗许多类型的癌症,包括某些血液恶性肿瘤和实体瘤。认为血液中I型干扰素的缺乏是严重COVID-19的标志性特征,可能为联合治疗方法提供理论依据。[RefSeq,2020年8月提供]
Related ID:
NCBI:3440
ENSEMBL:ENSG00000188379
HGNC:5423
UNIPROT:P01563
OMIM:147562
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
3440
1
1
1144 bp
21.58
15
--
17
21
IFNA2 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
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No data available
Transcripts & Proteins
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#
Transcript
Length(nt)
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CDS(bp)
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No data available
* This data comes from NCBI.
Gene Expression
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Name
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CAS Number
Status
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Link
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References Literature
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IF
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