Tmem67 - transmembrane protein 67

Predicted to enable filamin binding activity; misfolded protein binding activity; and unfolded protein binding activity. Involved in branching morphogenesis of an epithelial tube; cilium assembly; and negative regulation of centrosome duplication. Acts upstream of or within determination of left/right symmetry; heart development; and kidney development. Located in cytoplasmic vesicle membrane and endoplasmic reticulum membrane. Part of MKS complex. Is expressed in diencephalon; hindbrain lateral wall; metanephros; and organ of Corti. Used to study Joubert syndrome 6; Meckel syndrome; cystic kidney disease; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome (multiple); COACH syndrome; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis 11. Orthologous to human TMEM67 (transmembrane protein 67). [provided by Alliance of Genome Resources, Apr 2022]