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中文人类
HSD11B2 - Hydroxysteroid 11-beta Dehydrogenase 2
Alias:
AME
AME1
HSD2
HSD11K
SDR9C3
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皮质类固醇11-β脱氢酶至少有两种同工酶，这是一种负责将皮质醇和皮质素相互转换的微粒体酶复合物。I型同工酶具有11-β脱氢酶（皮质醇转化为皮质素）和11-氧还原酶（皮质素转化为皮质醇）活性。II型同工酶，由这个基因编码，只有11-β脱氢酶活性。在醛固酮选择性上皮组织如肾脏中，II型同工酶催化糖皮质激素皮质醇转化为无活性的代谢物皮质素，从而防止矿质皮质素受体的非法激活。在不表达矿质皮质素受体的组织中，如胎盘和睾丸，它保护细胞免受皮质醇的生长抑制和/或促凋亡作用，特别是在胚胎发育过程中。这个基因的突变导致明显的矿质皮质素过多和高血血压综合征。[RefSeq，2010年2月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
HSD11B2 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
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Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
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Residues
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Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
