人类

HSBP1 - Heat Shock Factor Binding Protein 1

Alias:
NPC-A-13
Favorite
Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
热休克反应是由细胞暴露在热和化学压力下引起的,通过激活HSFs(热休克因子)导致热休克诱导基因的表达增加。热休克因子结合蛋白1(HSBP1)是一种76个氨基酸的蛋白质,能与热休克因子1(HSF1)结合,HSF1是一种参与HS反应的转录因子。在HS反应中,HSF1经历从惰性非DNA结合单体到活性功能三聚体的构象转变。HSBP1是核定位的,与HSF1的活性三聚体状态相互作用,以负调控HSF1的DNA结合活性。在哺乳动物细胞中过表达HSBP1可抑制HSF1的转激活活性。在线虫中过表达HSBP1会对热和化学应激后的动物生存产生严重影响,这与HSBP1作为热休克反应负调控因子的作用一致。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
1
4
11760 bp
8.54
7
--
2
6

HSBP1 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
Wechat
Mutation Direct
Sequence
Comparison
Al agent
Tutorials
Back to top