Log In|Sign Up
中文人类
APC - APC Regulator Of WNT Signaling Pathway
Alias:
GS
DP2
DP3
BTPS2
DESMD
DP2.5
PPP1R46
Favorite
这个基因编码一种肿瘤抑制蛋白，作为Wnt信号通路拮抗剂发挥作用。它还涉及其他过程，包括细胞迁移和粘附、转录激活和凋亡。这个基因的缺陷导致家族性腺瘤性息肉病（FAP），这是一种常染色体显性恶性前疾病，通常进展为恶性肿瘤。APC基因的突变在大多数结直肠癌中发生，疾病相关的突变往往聚集在一个被称为突变簇区（MCR）的小区域内，并导致截断的蛋白质产物。[RefSeq，2022年6月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
APC Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
