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中文人类
APBB1 - Amyloid Beta Precursor Protein Binding Family B Member 1
Alias:
RIR
FE65
MGC:9072
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这个基因编码的蛋白质是Fe65蛋白质家族的一员。它是一个定位在细胞核的衔接蛋白。它与阿尔茨海默病的淀粉样前体蛋白（APP）、转录因子CP2/LSF/LBP1和低密度脂蛋白相关蛋白相互作用。APP作为胞质锚定位点，可以防止基因产物的核易位。这个编码的蛋白质可能在阿尔茨海默病的病理过程中发挥重要作用。它被认为可以调节转录。此外，还发现它可以通过下调胸苷酸合酶表达来阻止细胞周期进程。这个基因有多个可变剪接转录变异体，编码不同的异构体。[RefSeq，2012年3月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
APBB1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
