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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Lefty2 - left-right determination factor 2
Alias:
Ebaf
Lefta
Leftb
lefty-2
lefty-B
6030463A22Rik
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种分泌性的TGF-beta(转化生长因子-β)超家族蛋白质的配体。这个家族的配体结合各种TGF-beta受体,导致SMAD家族转录因子的招募和激活,从而调控基因表达。编码的前原原蛋白在蛋白水解过程中被加工成成熟的蛋白质,该蛋白质在发育过程中在器官系统的左右不对称性决定中发挥作用。该蛋白质在鼠胚胎干细胞的自我更新和分化中也具有重要意义。缺乏这个基因功能拷贝的小鼠表现出轴向和左右模式形成的缺陷。[RefSeq,2016年8月提供]
Related ID:
NCBI:320202
ENSEMBL:ENSMUSG00000066652
UNIPROT:P57785
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
320202
1
4
6000 bp
41.17
3
3
Lefty2 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
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Protein
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* This data comes from NCBI.
Gene Expression
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Type
Name
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