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中文人类
HMGCR - 3-hydroxy-3-methylglutaryl-CoA Reductase
Alias:
LDLCQ3
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羟甲基戊酸还原酶是胆固醇合成过程中的限速酶，其通过固醇和非固醇代谢产物介导的负反馈机制进行调节，这些代谢产物来自还原酶催化反应的产物甲羟戊酸。在哺乳动物细胞中，该酶通常受到来自低密度脂蛋白（LDL）内化和降解产生的胆固醇的抑制，这个过程是通过LDL受体实现的。还原酶的竞争性抑制剂可以诱导肝脏中LDL受体的表达，从而增加血浆LDL的分解代谢并降低胆固醇的血浆浓度，这是动脉粥样硬化的重要决定因素。已发现该基因存在编码不同异构体的可变剪接转录变异体。[RefSeq，2008年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
HMGCR Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
