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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
大鼠
Ago1 - argonaute RISC component 1
Alias:
Eif2c1
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码argonaute家族的一员,该家族与小型RNA结合并在RNA干扰(RNAi)和RNA沉默中扮演重要角色。这种蛋白质结合microRNAs(miRNAs)或小干扰RNAs(siRNAs),并抑制与其互补的mRNA的翻译。它还在与结合的短反义基因RNA(agRNAs)互补的启动子区域中的转录基因沉默(TGS)中发挥作用,以及在与miRNA结合的mRNA靶标中的降解。最近的研究表明,这个基因是一个真正的终止密码子穿透靶标,其mRNA可以通过使用可选的帧内翻译终止密码子产生一个C端延伸的异构体。[由RefSeq,2015年11月提供]
Related ID:
NCBI:313594
ENSEMBL:ENSRNOG00000055915
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
313594
6
19
35008 bp
Unknown
10
1
Ago1 Genetics information (-)
mRatBN7.2
Sequence Homology
Transcripts & Proteins
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Transcript
Length(nt)
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* This data comes from NCBI.
Gene Expression
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Name
MGI
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