Cyld - CYLD lysine 63 deubiquitinase

Predicted to enable several functions, including deubiquitinase activity; proline-rich region binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including protein deubiquitination; regulation of organelle organization; and regulation of signal transduction. Predicted to act upstream of or within several processes, including positive regulation of T cell receptor signaling pathway; regulation of lymphocyte differentiation; and ripoptosome assembly involved in necroptotic process. Predicted to be located in ciliary tip and microtubule cytoskeleton. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytosol. Predicted to colocalize with cytoplasmic microtubule and midbody. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase). [provided by Alliance of Genome Resources, Apr 2022]