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中文人类
HLA-DRA - Major Histocompatibility Complex, Class II, DR Alpha
Alias:
HLA-DRA1
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HLA-DRA是HLA二类α链平行基因群之一。这个二类分子是一个由α链和β链组成的异源二聚体，两者都固定在膜上。这个分子表达在各种抗原呈递细胞表面，如B淋巴细胞、树突状细胞和单核细胞/巨噬细胞，并在免疫系统中起核心作用，通过呈递来自细胞外蛋白质的肽，特别是病原体衍生的肽，以激活T细胞。α链约为33-35 kDa，其基因包含5个外显子。外显子1编码前导肽，外显子2和3编码两个细胞外结构域，外显子4编码跨膜结构域和细胞质尾。DRA在肽结合部分没有多态性，并作为DRB1、DRB3、DRB4和DRB5的唯一α链发挥作用。[由RefSeq，2020年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
HLA-DRA Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
