Itch - itchy E3 ubiquitin protein ligase

Predicted to enable several functions, including arrestin family protein binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein ligase binding activity. Predicted to be involved in several processes, including negative regulation of JNK cascade; negative regulation of NF-kappaB transcription factor activity; and protein ubiquitination. Predicted to act upstream of or within several processes, including cellular protein metabolic process; negative regulation of alpha-beta T cell proliferation; and positive regulation of T cell anergy. Predicted to be located in several cellular components, including cell cortex; cytoplasmic vesicle; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to colocalize with early endosome. Orthologous to human ITCH (itchy E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2022]