Plekhg5 - pleckstrin homology and RhoGEF domain containing G5

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including endothelial cell chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB signaling; and regulation of protein catabolic process at presynapse, modulating synaptic transmission. Predicted to be located in cell-cell junction; cytoplasm; and lamellipodium. Predicted to be active in axon; endocytic vesicle; and plasma membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and distal spinal muscular atrophy type 4. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5). [provided by Alliance of Genome Resources, Apr 2022]