Log In|Sign Up
中文人类
HLA-B - Major Histocompatibility Complex, Class I, B
Alias:
AS
HLAB
B-4901
Favorite
HLA-B属于HLA I类重链平行系。这个I类分子是一个由重链和轻链（β2微球蛋白）组成的异二聚体，重链位于细胞膜中。I类分子在免疫系统中扮演着核心角色，通过呈现来自内质网腔的肽段。它们在几乎所有细胞中表达。重链约45kDa，其基因包含8个外显子。外显子1编码前导肽，外显子2和3编码与肽结合的alpha1和alpha2结构域，外显子4编码alpha3结构域，外显子5编码跨膜区域，外显子6和7编码胞质尾。外显子2和外显子3中的多态性决定了每个I类分子的肽结合特异性。这些多态性的分型通常用于骨髓和肾脏移植。已经描述了数百种HLA-B等位基因。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
HLA-B Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
