RT1-Ba - RT1 class II, locus Ba

Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Involved in cellular response to glucocorticoid stimulus and negative regulation of T cell proliferation. Predicted to be located in external side of plasma membrane and lysosome. Predicted to be part of MHC class II protein complex. Used to study uveitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); glomerulonephritis (multiple); hematologic cancer (multiple); and systemic scleroderma (multiple). Orthologous to several human genes including HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1). [provided by Alliance of Genome Resources, Apr 2022]