小鼠

Kdm2b - lysine (K)-specific demethylase 2B

Alias:
Cxxc2
Fbl10
PCCX2
Fbxl10
Jhdm1b
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质是一种特异性的H3K36组蛋白去甲基化酶,它包含一个N-端jumonji C结构域,一个CxxC锌指结构域,一个植物同源结构域手指,一个F-box和八个富含亮氨酸的重复序列。已证明该蛋白质具有抑制细胞过早衰老、维持和开发白血病、维持小鼠胚胎干细胞的全能性以及诱导多能干细胞生成等功能。锌指结构域被靶向删除的小鼠表现为胚胎致死,发育在交配后大约7到8天停止,这表明在早期发育中具有重要作用。该基因的一个假基因位于染色体4上。可变剪接导致多个转录变异体。[RefSeq,2014年10月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
18
23
118607 bp
149.73
14
5

Kdm2b Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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