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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Kdm2b - lysine (K)-specific demethylase 2B
Alias:
Cxxc2
Fbl10
PCCX2
Fbxl10
Jhdm1b
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质是一种特异性的H3K36组蛋白去甲基化酶,它包含一个N-端jumonji C结构域,一个CxxC锌指结构域,一个植物同源结构域手指,一个F-box和八个富含亮氨酸的重复序列。已证明该蛋白质具有抑制细胞过早衰老、维持和开发白血病、维持小鼠胚胎干细胞的全能性以及诱导多能干细胞生成等功能。锌指结构域被靶向删除的小鼠表现为胚胎致死,发育在交配后大约7到8天停止,这表明在早期发育中具有重要作用。该基因的一个假基因位于染色体4上。可变剪接导致多个转录变异体。[RefSeq,2014年10月提供]
Related ID:
NCBI:30841
ENSEMBL:ENSMUSG00000029475
UNIPROT:Q6P1G2
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
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30841
18
23
118607 bp
149.73
14
5
Kdm2b Genetics information (-)
GRCm39
Sequence Homology
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* This data comes from NCBI.
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