人类

HGF - Hepatocyte Growth Factor

Alias:
SF
HGFB
HPTA
F-TCF
DFNB39
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一个蛋白质,该蛋白质与肝细胞生长因子受体结合,以调节多种细胞和组织类型中的细胞生长、细胞迁移和形态发生。选择性剪接导致多个转录变异体,至少其中一个编码前原蛋白,该前原蛋白在蛋白水解过程中被处理以生成α和β链,它们形成成熟的异源二聚体。这种蛋白质由间充质细胞分泌,并在主要来源于上皮细胞的细胞上发挥多功能的细胞因子作用。这种蛋白质在血管生成、肿瘤生成和组织再生中也发挥作用。尽管编码的蛋白质是丝氨酸蛋白酶肽酶S1家族的成员,但它没有肽酶活性。这个基因的突变与非综合征性听力损失有关。[RefSeq, Nov 2015提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
6
18
71038 bp
83.13
208
2
7
24

HGF Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
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