Bmi1 - BMI1 proto-oncogene, polycomb ring finger

Predicted to enable several functions, including RING-like zinc finger domain binding activity; promoter-specific chromatin binding activity; and zinc ion binding activity. Involved in cellular response to dexamethasone stimulus and cellular response to interleukin-1. Predicted to be located in cytosol; heterochromatin; and nuclear body. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; and hepatocellular carcinoma. Orthologous to several human genes including COMMD3-BMI1 (COMMD3-BMI1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]