Flcn - folliculin

Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including regulation of intracellular signal transduction; regulation of nucleobase-containing compound metabolic process; and regulation of protein modification process. Predicted to act upstream of or within with a positive effect on negative regulation of cell population proliferation. Predicted to act upstream of or within positive regulation of intrinsic apoptotic signaling pathway. Predicted to be located in several cellular components, including cilium; lysosomal membrane; and microtubule cytoskeleton. Predicted to be active in cytosol. Predicted to colocalize with cell-cell contact zone and midbody. Used to study renal cell carcinoma. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin). [provided by Alliance of Genome Resources, Apr 2022]