Atm - ATM serine/threonine kinase

Predicted to enable identical protein binding activity; phosphotransferase activity, alcohol group as acceptor; and protein N-terminus binding activity. Involved in several processes, including positive regulation of neuron apoptotic process; positive regulation of nitrogen compound metabolic process; and regulation of microglial cell activation. Located in cytoplasm and nucleus. Used to study ataxia telangiectasia; disease of cellular proliferation; infertility; leukemia; and lymphoma. Biomarker of pre-malignant neoplasm and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; endometrial cancer; lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]