Sgk1 - serum/glucocorticoid regulated kinase 1

Enables 3-phosphoinositide-dependent protein kinase binding activity; protein serine/threonine kinase activity; and tau protein binding activity. Involved in several processes, including generation of neurons; glucocorticoid mediated signaling pathway; and learning or memory. Acts upstream of or within cellular response to insulin stimulus; positive regulation of sodium ion transport; and regulation of protein localization. Located in neuron projection; nucleus; and perinuclear region of cytoplasm. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]