Slc22a2 - solute carrier family 22 member 2

Enables several functions, including organic cation transmembrane transporter activity; toxin transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including cation transport; quaternary ammonium group transport; and toxin transport. Acts upstream of or within positive regulation of gene expression. Located in apical plasma membrane and basolateral plasma membrane. Is integral component of plasma membrane. Used to study acute kidney failure. Biomarker of cholestasis (multiple); hyperuricemia; and kidney failure (multiple). Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2). [provided by Alliance of Genome Resources, Apr 2022]