人类

GSTA2 - Glutathione S-transferase Alpha 2

Alias:
GST2
GTA2
GTH2
GSTA2-2
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
细胞质和膜结合形式的谷胱甘肽S-转移酶由两个不同的超基因家族编码。这些酶在电子亲合化合物的解毒中发挥作用,包括致癌物质、治疗药物、环境毒素和氧化应激产物,通过与谷胱甘肽结合。编码这些酶的基因已知具有高度多态性。这些遗传变异可以改变个体对致癌物质和毒素的敏感性,以及影响某些药物的毒性和疗效。目前,已确定了八种不同的可溶性细胞质哺乳动物谷胱甘肽S-转移酶类:α、κ、μ、ω、π、σ、θ和ζ。这个基因编码属于α类的谷胱甘肽S-转移酶。α类基因位于定位于染色体6的簇中,是肝脏中丰度最高的谷胱甘肽S-转移酶。除了代谢肝脏中的胆红素和某些抗癌药物外,这些酶的α类还具有谷胱甘肽过氧化物酶活性,从而保护细胞免受活性氧物种和过氧化产物的损害。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
2
7
13389 bp
25.66
9
--
5
12

GSTA2 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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