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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
GSTA2 - Glutathione S-transferase Alpha 2
Alias:
GST2
GTA2
GTH2
GSTA2-2
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
细胞质和膜结合形式的谷胱甘肽S-转移酶由两个不同的超基因家族编码。这些酶在电子亲合化合物的解毒中发挥作用,包括致癌物质、治疗药物、环境毒素和氧化应激产物,通过与谷胱甘肽结合。编码这些酶的基因已知具有高度多态性。这些遗传变异可以改变个体对致癌物质和毒素的敏感性,以及影响某些药物的毒性和疗效。目前,已确定了八种不同的可溶性细胞质哺乳动物谷胱甘肽S-转移酶类:α、κ、μ、ω、π、σ、θ和ζ。这个基因编码属于α类的谷胱甘肽S-转移酶。α类基因位于定位于染色体6的簇中,是肝脏中丰度最高的谷胱甘肽S-转移酶。除了代谢肝脏中的胆红素和某些抗癌药物外,这些酶的α类还具有谷胱甘肽过氧化物酶活性,从而保护细胞免受活性氧物种和过氧化产物的损害。[由RefSeq,2008年7月提供]
Related ID:
NCBI:2939
ENSEMBL:ENSG00000244067
HGNC:4627
UNIPROT:P09210
OMIM:138360
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
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Reference
2939
2
7
13389 bp
25.66
9
--
5
12
GSTA2 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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