Pidd1 - p53-induced death domain protein 1

Predicted to enable endopeptidase activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; activation of cysteine-type endopeptidase activity involved in apoptotic process; and protein autoprocessing. Predicted to act upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in Golgi apparatus; cytosol; and nucleus. Predicted to be active in cytoplasm. Orthologous to human PIDD1 (p53-induced death domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]