Drd3 - dopamine receptor D3

Enables D1 dopamine receptor binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and protein domain specific binding activity. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; regulation of secretion; and regulation of transcription by RNA polymerase II. Located in several cellular components, including apical part of cell; endocytic vesicle; and plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane. Used to study Parkinsonism; amnestic disorder; essential tremor; and hypertension. Biomarker of heroin dependence and visual epilepsy. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3). [provided by Alliance of Genome Resources, Apr 2022]