Cnot1 - CCR4-NOT transcription complex, subunit 1

Predicted to enable armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; negative regulation of signal transduction; and positive regulation of mRNA catabolic process. Predicted to be located in cytosol. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]