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中文人类
GRM6 - Glutamate Metabotropic Receptor 6
Alias:
mGlu6
CSNB1B
GPRC1F
MGLUR6
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L-谷氨酸是中枢神经系统中的主要兴奋性神经递质，可激活离子型和非离子型谷氨酸受体。谷氨酸能神经传导涉及正常大脑功能的大部分方面，并在许多神经病理学条件下受到干扰。非离子型谷氨酸受体是一类G蛋白偶联受体家族，根据序列同源性、推测的信号传导机制和药理学特性已分为3组。I组包括GRM1和GRM5，已显示这些受体可激活磷脂酶C。II组包括GRM2和GRM3，而III组包括GRM4、GRM6、GRM7和GRM8。II组和III组受体与环腺苷酸级联的抑制相连，但在其激动剂选择性方面有所不同。此基因的突变导致先天性静止性夜盲1B型。[RefSeq，2018年5月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
GRM6 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
