Actn2 - actinin alpha 2

Predicted to enable several functions, including cytoskeletal protein binding activity; nuclear receptor coactivator activity; and protein domain specific binding activity. Predicted to be involved in several processes, including focal adhesion assembly; muscle cell development; and regulation of ion transmembrane transporter activity. Predicted to act upstream of or within muscle contraction. Is active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic density, intracellular component. Colocalizes with cortical actin cytoskeleton. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and dilated cardiomyopathy 1AA. Orthologous to human ACTN2 (actinin alpha 2). [provided by Alliance of Genome Resources, Apr 2022]