Irf4 - interferon regulatory factor 4

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including T-helper 17 cell lineage commitment; positive regulation of cytokine production; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including histone acetylation; myeloid dendritic cell differentiation; and negative regulation of toll-like receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in nucleus. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; anaplastic large cell lymphoma; chronic lymphocytic leukemia; multiple myeloma; and peripheral T-cell lymphoma. Orthologous to human IRF4 (interferon regulatory factor 4). [provided by Alliance of Genome Resources, Apr 2022]