Nsd3 - nuclear receptor binding SET domain protein 3

Predicted to enable histone-lysine N-methyltransferase activity and transcription regulator activator activity. Predicted to be involved in histone methylation; positive regulation of histone H3-K36 trimethylation; and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of transcription, DNA-templated. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human NSD3 (nuclear receptor binding SET domain protein 3). [provided by Alliance of Genome Resources, Apr 2022]