Appl1 - adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

Predicted to enable several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; cellular response to hepatocyte growth factor stimulus; and regulation of vesicle-mediated transport. Predicted to be located in several cellular components, including cytoplasmic vesicle; ruffle; and vesicle membrane. Predicted to be active in endosome membrane. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1). [provided by Alliance of Genome Resources, Apr 2022]