Nrl - neural retina leucine zipper

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; leucine zipper domain binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and retinal rod cell development. Predicted to act upstream of or within positive regulation of gene expression and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 27. Orthologous to human NRL (neural retina leucine zipper). [provided by Alliance of Genome Resources, Apr 2022]