人类

GRN - Granulin Precursor

Alias:
GEP
GP88
PEPI
PGRN
CLN11
PCDGF
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
粒细胞素是一家族分泌的、糖基化的肽,从具有7.5个高度保守的12个半胱氨酸粒细胞素/上皮样主题的单个前体蛋白中切割而成。88kDa的前体蛋白,progranulin,也被称为proepithelin和PC细胞衍生的生长因子。信号肽的切割产生成熟的粒细胞素,其可以进一步切割成各种活性、6kDa的肽。这些较小的切割产物被称为粒细胞素A、粒细胞素B、粒细胞素C等。上皮样1和2分别与粒细胞素A和B同义。肽和完整的粒细胞素蛋白都调节细胞生长。然而,粒细胞素蛋白家族的成员可能作为抑制剂、刺激剂或对细胞生长的双重作用。粒细胞素家族成员在正常发育、创伤愈合和肿瘤发生中起着重要作用。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
1
13
7805 bp
63.54
582
9
19
28

GRN Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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