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中文人类
TRIB2 - Tribbles Pseudokinase 2
Alias:
C5FW
TRB2
GS3955
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这个基因编码Tribbles家族的三个成员之一。Tribbles成员共享一个Trb结构域，该结构域与蛋白质丝氨酸-苏氨酸激酶同源，但缺乏活性位点的赖氨酸，可能缺乏催化功能。Tribbles蛋白相互作用并调节许多生理和病理过程中的信号传导途径的活性。这个Tribbles成员诱导主要来源于造血细胞的细胞的凋亡。它已被鉴定为在髓样(THP-1)细胞中由炎症刺激上调的蛋白质，并作为一种使转录因子C/EBPalpha(CCAAT/增强子结合蛋白alpha)失活并导致急性髓系白血病的癌基因。已发现该基因的替代剪接转录变异体。[RefSeq，2009年3月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
TRIB2 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
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