Tdrd5 - tudor domain containing 5

This gene encodes a member of the tudor domain-containing protein family. Tudor domain-containing proteins regulate a variety of processes including RNA metabolism, histone modification, and the DNA damage response. The tudor domain commonly functions to link methylated arginine or lysine marks to downstream effector proteins. In mouse, this gene is expressed in the primordial germ cells and in male germ cells during embryogenesis. In addition, it is expressed in adult testis cells where the protein is a component of the intermitochondrial cement and chromatoid bodies. Loss-of-function mutations in mouse result in arrest of spermatogenesis. [provided by RefSeq, Mar 2015]