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中文人类
GPS2 - G Protein Pathway Suppressor 2
Alias:
AMF-1
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这个基因编码一种参与G蛋白-促细胞分裂原激活蛋白激酶(MAPK)信号级联的蛋白质。当在哺乳动物细胞中过度表达时，这个基因可以有效地抑制RAS和MAPK介导的信号，并干扰JNK活性，表明这个基因的功能可能是信号抑制。编码的蛋白质是NCOR1-HDAC3(核受体核心抑制子1-组蛋白脱乙酰酶3)复合物的整合亚基，研究表明该复合物通过这个亚基抑制JNK激活，从而可能为激素介导的AP1(激活蛋白1)功能的拮抗提供另一种机制。[由RefSeq,2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
GPS2 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
