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中文人类
GP1BA - Glycoprotein Ib Platelet Subunit Alpha
Alias:
BSS
GP1B
VWDP
CD42B
GPIbA
BDPLT1
BDPLT3
DBPLT3
GPIbalpha
CD42b-alpha
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糖蛋白Ib（GP Ib）是一种由异二聚体α链和β链组成的血小板表面膜糖蛋白，通过二硫键连接。Gp Ib作为von Willebrand因子的受体发挥作用。完整的受体复合物包括α和β亚单位与非共价结合的血小板糖蛋白IX和血小板糖蛋白V。GP Ib-IX-V复合物与VWF的结合有助于血小板在血管损伤后最初粘附到内皮下层，并在血小板内启动信号事件，导致血小板激活、血栓形成和止血增强。此基因编码α亚单位。此基因的突变导致Bernard-Soulier综合征和血小板型von Willebrand病。此基因的编码区域已知包含与非动脉硬化性前缺血性视神经病变易感性相关的多态性可变数串联重复（VNTR）结构域。[RefSeq，2013年10月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
GP1BA Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
