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中文人类
GNRHR - Gonadotropin Releasing Hormone Receptor
Alias:
HH7
GRHR
LRHR
LHRHR
GNRHR1
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这个基因编码1型促性腺激素释放激素受体。这个受体是七跨膜G蛋白耦合受体（GPCR）家族的成员。它表达在脑垂体促性腺细胞表面以及淋巴细胞、乳腺、卵巢和前列腺上。结合促性腺激素释放激素后，受体与G蛋白结合，激活磷脂酰肌醇-钙第二信使系统。受体的激活最终导致促性腺激素黄体生成素（LH）和卵泡刺激激素（FSH）的释放。这个基因的缺陷是导致促性腺激素不足性腺功能减退（HH）的原因。可变剪接导致多个转录变异体编码不同的异构体。这个基因的5'区域已经确定了超过18个转录起始位点，3'区域已经确定了多个polyA信号。[RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
GNRHR Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
