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中文人类
SESN1 - Sestrin 1
Alias:
PA26
SEST1
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这个基因编码sestrin家族的一员。Sestrins由p53肿瘤抑制蛋白诱导，在细胞对DNA损伤和氧化应激的反应中发挥作用。编码的蛋白质通过激活AMP激活的蛋白激酶来调节p53对细胞生长的抑制，从而导致哺乳动物雷帕霉素靶蛋白的抑制。该编码的蛋白质还通过再生过度氧化的过氧化还原蛋白在抗氧化防御中扮演关键角色，并且这个基因的表达是辐射暴露的潜在标志。已经观察到了这个基因的替代剪接转录变异体，它们编码多种异构体。[RefSeq,2010年12月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
SESN1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
