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中文人类
BBC3 - BCL2 Binding Component 3
Alias:
JFY1
PUMA
JFY-1
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这个基因编码BCL-2家族蛋白质的一员，这个家族成员属于BH3-only促凋亡子类。该蛋白质与直接的激活蛋白合作，诱导线粒体外膜通透性增加和细胞凋亡。它可以结合抗凋亡的Bcl-2家族成员，诱导线粒体功能障碍和caspase激活。由于其促凋亡作用，这个基因是癌症治疗和组织损伤的潜在药物靶点。可变剪接导致多个转录变异体。[由RefSeq，2011年12月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
BBC3 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
