Tcirg1 - T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3

Predicted to enable ATPase binding activity. Acts upstream of or within several processes, including T cell activation; animal organ development; and cellular cation homeostasis. Located in several cellular components, including cytoplasmic vesicle; lysosome; and nucleus. Is expressed in several structures, including ciliary body; future brain; hemolymphoid system gland; metanephros; and optic choroid plus pigmented retinal epithelium. Used to study autosomal recessive osteopetrosis 1 and clubfoot. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 1. Orthologous to human TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3). [provided by Alliance of Genome Resources, Apr 2022]