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中文人类
LAT - Linker For Activation Of T Cells
Alias:
LAT1
pp36
IMD52
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这个基因编码的蛋白质在T细胞抗原受体（TCR）信号转导途径激活后，被ZAP-70/Syk酪氨酸激酶磷酸化。这种跨膜蛋白定位到脂质筏中，并作为含SH2结构域蛋白的停靠位点。被磷酸化后，这个蛋白质将多个衔接蛋白和下游信号分子招募到位于TCR结合位点附近的多元信号复合体中。可变剪接产生多个转录变异体，编码不同的异构体。[RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
LAT Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
